homebooksjournalsfor authors
 

 

IUL Biotechnology Series

       HOME
c
    Products & Services
    BOOKS

     SPECIAL OFFERS

     RECENTLY RELEASED
    
BOOKS

     BOOKS IN PRINT

     FORTHCOMING 
     BOOKS

     BOOKS BY SERIES

     CUSTOMER SERVICE


    Resources

    FOR BOOKSELLERS

    FOR AUTHORS

    FOR EDITORS

 

 
   HOW TO ORDER
 
    CONTACT US

 

  Comparative Enzymology of Cholinesterases

IUL Biotechnology Series, 6

by Serge Moralev and Eugene Rozengart (Authors) 

Edition: First




 

 


Book Details:
  • Series: IUL Biotechnology Series

  • Volume: 6

  • Binding: Hardcover 

  • Pages: 500

  • Dimensions (in inches): 1.25 x 9.5 x 6.50

  • Publisher: International University Line 

  • Publication Date: March, 2007

  • ISBN-10: 0-9720774-2-1

  • ISBN-13:  978-0-9720774-2-2
  • List Price: $119.95

  • Price: $119.95


Editorial Reviews
In review Book News, Inc.®, Portland, OR

Reviews
Dr. Leo Pezzementi, Birmingam-Southern College, Alabama
It has been more than thirty years since a book on cholinesterases of the ambitious scope and magnitude of Comparative Enzymology of Cholinesterases by S.N.Moralev and E.V.Rozengart has been available to Western readers. The previous book to which I refer, Biology of Cholinesterases by Ann Silver, was published in 1974 and synthesized much of the biological work in the field at that time. However, it was printed just before the discovery of the multiple molecular forms of cholinesterases and well ahead of the advent of cholinesterase molecular biology. Nevertheless, the book was a source of information, ideas, and inspiration for a generation of cholinesterase researchers. As a newcomer to the field at the time, who was interested in the structure, function, and evolution of cholinesterases, I found the comparative biological approach of Silver particularly valuable. It is well past time for a similarly comprehensive text summarizing the advancements in the research of cholinesterase over the past thirty years to be published. Moralev and Rozengart have responded to this need in a comprehensive book that reflects the changing times and the changing methodologies of cholinesterase research. The authors again take a comparative approach to cholinesterase research, but this time from a molecular/biochemical point of view rather than from a biological point of view. They synthesize a wide range of results from kinetics, pharmacology, and molecular biology, and apply these results to an investigation of the structure, function, and evolution of the cholinesterases in the vertebrates and the invertebrates. The authors consider the effect of substrate structure on substrate specificity and inhibition, and how these different inhibitors can be used alone and in conjunction with reversible and irreversible inhibitors to probe the various sub-sites of the active site of various cholinesterases.


 

 

Comparative Enzymology of Cholinesterases

see larger photo

Look inside this book

 

Abstract:

This book fills the interdisciplinary gap between the integrated biology of cholinesterase actions and their kinetic mechanisms. It covers structural and mechanistic data on cholinesterase enzymes from a wide variety of living species and their interactions with a diverse and original collection of substrate and inhibitor compounds. The book includes six chapters and appendices. The first part of the book (Chapters 1–4) deals with classical aspects of cholinesterase specificity in substrate hydrolysis, inhibition by reversible inhibitors, and progressive (“irreversible”) inhibition by organophosphorus compounds and carbamates. The second part of the book (Chapters 5 and 6) deals with the theoretical basis and the application of substrate–inhibitor specificity for solving some practical problems: (a) calculation of inhibitor selectivity toward different enzymes for identification of reversible and irreversible inhibitors; and (b) the use of specificity constants for molecular phylogenetic analysis of the active center of cholinesterases and esterases. Comparison of computerized dendograms with phylogenetic trees provides evolutionary and taxonomic information that can lead to readjustments in the enzyme nomenclature.

 

  Dr. Patrick Masson, Centre de Recherches, La Tronche, France



The authors have to be congratulated for their comprehensive synthesis of a considerable body of scattered works. This book has to be regarded as a reference book and a source of information. We hope that it will be useful to students entering the field of cholinesterase research, and that it will be a valuable guide for enzymologists, molecular pharmacologists, and toxicologists aware of the usefulness of experimental approaches in rational drug research and enzyme engineering.



Drs. Zoran Radič and Palmer Taylor, University of California, San Diego



Over the years, several textbooks on cholinesterases have become widely accepted and used as references in this field. Dr. Ann Silver comprehensive book Biology of Cholinesterases, published in 1974, and Drs. Norman Aldridge and Elsa Reiner elegant text Enzyme Inhibitors as Substrates, with focus on enzyme kinetics, published in 1972, are prime examples. The Moralev and Rozengart Comparative Enzymology of Cholinesterases should join this list of comprehensive treatises and fill the interdisciplinary gap between the integrated biology of cholinesterase actions and their kinetic mechanisms. It covers structural and mechanistic data on cholinesterase enzymes from a wide variety of living species and their interactions with a diverse and original collection of substrate and inhibitor compounds.