Computational repurposing of existing drugs for treatment of COVID-19

    $55.00

    The book contains eight chapters. First, we have a chapter describing all non-structural proteins of SARS‑Cov2 and their features that make them possible targets of medications. Then we put the chapter devoted to elucidation of possible inhibitors of ACE2 and Spike Protein of SARS-Cov2. This is the virus entrance route, and its inhibition may play a significant role in prevention or mitigation of the virus penetration to the organism. Following are the chapters devoted to repurposing the drugs for inhibiting of several NSPs: NSP3—papain-like protease PLpro, NSP15— endoribonuclease, and NSP5—main protease Mpro. After that a reader find chapters describing more complex studies devoted to finding of possible simultaneous inhibitors of most of the NSPs, concentrating to the possibility to elucidate the drugs that target more than one NSP. This study was done using information of drug-target interaction (DTI) and predicted several drugs that can simultaneously inhibit several NSPs. Two last chapters are devoted to treatment of cytokine storm, concentrating on possible simultaneous impact on several cytokines-related pathways.

    All the studies were conducted using various machine-learning tools and give a lot of details of the approach that make it possible to use these methods by other scientists and students.

    7 in stock

    Computational repurposing of existing drugs for treatment of COVID-19

    $55.00